If you've spent enough time on pretty much any social media platform, you've likely seen at least one clip of someone users have taken to calling a "Karen" making a scene about some store's face mask policy or threatening people of color on the basis of their race.
As the name would suggest, this label tends to fall on middle aged women who exhibit this behavior, while men who do so may find themselves characterized as "Kens" or "Kevins" but there's far less of a consensus with them than there is with Karens.
It's likely for this reason that some women who happened to be named Karen are now pushing back against the meme that now makes their name unpopular.