She's been a staple in Hollywood for decades, with iconic roles in Thelma & Louise, Stepmom, and The Rocky Horror Picture Show.
In her personal life, she's also one interesting woman. Did you know that she got into acting by accident? Or that she raised her children to ignore gender norms?
She also has quite the reputation as a cougar...
While she had majored in drama at the Catholic University of America in Washington, she never saw acting as a career.
But that all changed when she tagged along with her first husband, Chris Sarandon, to an audition.
She took acting seriously after that, and even moved to New York, where she landed her first role as a troubled teenager in the movie, Joe in 1970.
It actually belongs to her first husband. Chris Sarandon. The two were married on September 16, 1967, when Susan was only 20.
When they got divorced, Susan kept his last name as a stage name.
As the oldest, she told The Daily Beast that she "mothered" all of them.
This made it all the more surprising for the actress to have her own kids since she never wanted them.
"He's worth idolising. He's extraordinary," Susan told The Daily Beast of Bowie, who she met while filming the British horror flick, The Hunger.
"That was a really interesting period," she added.
The actress has done more soaps than just playing a soap star on Friends.
In the early days of her career, she appeared on Search for Tomorrow and A World Apart.
They met while filming Bull Durham. They had two sons together: Jack and Miles.
Susan also has a daughter, Eva, who she had with director Franco Amurri.
She won the prestigious award for her role in 1995's Dead Man Walking.
After keeping it in her guest bathroom for years, the award became one of the pieces in a traveling exhibit on gold.
It's uncertain whether she has it back now.
Back in 2011, she told The Hollywood Reporter that she hasn't seen it for a few years.
It was a real-life horror story for the actress who played the heroine Jane Weiss in the cult-classic.
She caught pneumonia due to the house on set since it had no roof to shield it from freezing rain.
“And what they could do was either put me in a hot bath or warm me up between each [scene]."
She continued on, saying that the producers weren't happy that they had to keep her warm.
"And so what they did do was they created a screen that they put space heaters in so there was one warm place to go. And everybody went in there, and then it went up in flames, and that was the end of that.”
The actress certainly has a thing for younger men (her ex-husband, Tim Robbins, was 12 years younger).
The actress met the screenwriter, Jonathan Bricklin, in Chile in 2010.
Back in 2016, Sarandon was a vocal supporter of Bernie Sanders for the next President.
When he lost out on the nomination, she aired her frustrations online, bringing down Hillary Clinton with her.
“I have had a huge amount of backlash,” she told The Guardian.
“There’s been a really strong blame for a lot of things that are obviously not my fault.”
“I couldn’t give you any solid proof that has hurt my chances in the business. Today in the New York Times, they were talking about the Academy awards and the fact that I was one of the people who didn’t get a nomination for The Meddler, and [it] mentions that it might have something to do with the Clintonized Hollywood, when I supported Bernie Sanders.”
Susan told People magazine that her son, Miles, likes to "colors outside the lines" of gender roles.
"My son Miles is a musician and a DJ and sometimes when his band performs they all wear dresses, and he has long hair."
“I wanted to raise my kids in New York because, as a privileged kid, I think you can become very isolated and at least if you’re privileged, you should understand you’re privileged, and not take it for granted.”
